Difference Between Lorazepam and Diazepam

Edited by Diffzy | Updated on: April 30, 2023


Difference Between Lorazepam and Diazepam

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The medications lorazepam and diazepam are benzodiazepines, a class of psychoactive pharmaceuticals that includes lorazepam and diazepam. These affect the brain's neurotransmitters. As mild sedatives or anxiety relievers, these have a relaxing impact on stressed nerves.

Lorazepam has several advantages over diazepam in the treatment of status epileptics, including a faster onset of convulsions. Lorazepam has a long-lasting effect on the body. The effect of diazepam appears after 6-10 months of treatment, making it a viable alternative for long-term maintenance therapy. Diazepam is particularly useful in cases of eclampsia emergency, especially when blood pressure has failed to stay under control despite other interventions.

Lorazepam and diazepam are generic medications that are used to treat anxiety disorders and other mental illnesses. Benzodiazepines are a class of medications that includes both of these substances. They function by boosting GABA (gamma-aminobutyric acid) activity in the brain. The neurotransmitter GABA is an inhibitory molecule that boosts mood and promotes calm by blocking certain nerve messages.

According to the Drug Enforcement Administration, lorazepam and diazepam are both Schedule IV substances (DEA). This means that, like other benzodiazepines, these medications carry the risk of addiction and abuse. As a result, they should only be used as a short-term treatment under the guidance of a physician.

Lorazepam vs Diazepam

The key distinction between lorazepam and diazepam is that diazepam lasts longer in the body. Lorazepam, the generic name for Ativan, has a half-life of up to 18 hours. Diazepam, the generic name for Valium, on the other hand, has a half-life of up to 48 hours. As a result, lorazepam is classified as a mid-acting benzodiazepine, while diazepam is classified as a long-acting benzodiazepine.

Lorazepam and diazepam are metabolized or digested differently in the body. Lorazepam is metabolized in the liver through the glucuronidation mechanism. Diazepam is broken down by cytochrome enzymes in the liver. As a result, diazepam is more likely than lorazepam to interact with other medicines.

Lorazepam comes in 0.5 mg, 1 mg, and 2 mg concentrations in generic oral tablets. It's also available as an oral solution and an injectable solution. Ativan comes in dosages of 5 mg, and 10 mg as generic oral pills. Ativan is also available as an oral solution, an injectable solution, and a rectal gel.

Anxiolytics like lorazepam and diazepam relieve anxiety symptoms such as excessive stress and problems thinking rationally. Both lorazepam and diazepam have been approved by the FDA to treat anxiety and anxiety disorders such as panic attacks and panic disorders.

Lorazepam and diazepam, like other benzodiazepines, can be used to treat seizure disorders including epilepsy. They can also be used as a sedative premedication before surgery.

According to the FDA, diazepam is also used to manage liquor symptoms of withdrawal and muscle aches. Lorazepam is licensed for treating sleeplessness caused by anxiety in addition to treating anxiety. The table below contains further off-label usage.

Both lorazepam and diazepam help treat helpful for treating anxiety when compared to placebo or no medication. The most effective benzodiazepine will be determined by the ailment being treated, any other drugs being taken, and any past therapies.

Lorazepam and diazepam have mostly been found to be equal in terms of effectiveness in treating anxiety in randomized, controlled clinical trials. One four-week double-blind clinical investigation indicated that both lorazepam and diazepam were more helpful than saline in 134 distressed patients. Lorazepam, on the other hand, was found to be more beneficial in patients who had initially worse symptoms. Sedation was found to be a more common side effect in the lorazepam group.

Midazolam, lorazepam, and diazepam were examined in a network meta-analysis for treating status epilepticus, a severe protracted seizure in children. Midazolam and lorazepam were proven to be more effective than diazepam in 16 distinct clinical investigations.

This comparison is provided for educational purposes only. Before using a benzodiazepine, seek medical advice from a doctor or healthcare provider. To evaluate the severity of your issue and rule out any possible mental health conditions, your healthcare professional will undertake a complete medical evaluation.

Difference Between Lorazepam and Diazepam in Tabular Form

Parameters of Comparison Lorazepam Diazepam
Effect Lorazepam is a short-acting benzodiazepine with a half-life of about 18 hours. Diazepam takes time to take effect and has a half-life of up to 48 hours.
Digestion Lorazepam is broken down in the liver by a process known as glucuronidation. Diazepam is broken down in the liver by cytochrome enzymes.
Causes Lorazepam was once thought to function faster and better for those with severe symptoms. Diazepam was initially shown to be slower for those with severe symptoms.
Cost Lorazepam is a little more expensive. Diazepam is a less expensive option.
Brand Lorazepam is sold under the brand name Ativan. Diazepam is sold under the brand name Valium.

What is Lorazepam?

This medication is used to alleviate anxiety. Lorazepam belongs to the benzodiazepine class of drugs, which have a calming effect on the brain and nerves (central nervous system). This drug works by enhancing the effects of a naturally occurring chemical in the body (GABA).

Take the medication by mouth, with or without food, as prescribed by the doctor. Your medical condition, age, and therapy response all influence the dose. Take this medicine regular basis as directed by your doctor to get the maximum benefit from it. To aid recall, use it at the same time every day.

Even though it aids a large number of people, this medication has the potential to cause addiction. Your risk may be enhanced if you have a substance use problem (such as misuse or addiction to drugs). Take these drugs exactly as prescribed to minimize the chances of addiction.

Do not stop taking this medication abruptly without first visiting your doctor. Several symptoms may worsen if this medication is abruptly stopped. It's conceivable that your dose will have to be reduced gradually. When this medication is used for a long time, it may lose its effectiveness. If this medication isn't working properly, talk to your doctor.

Buying lorazepam over the internet or from a country other than the United States is risky. The sales and delivery of medications outside the United States violate the Food and Drug Administration's safe-use standards (FDA). These medications may contain dangerous ingredients or be distributed by a pharmacy that is not certified.

Follow your doctor's instructions for taking lorazepam. Study all drug guidelines or instruction sheets and follow the directions on your prescription label. Never use more lorazepam than prescribed or for longer than recommended. If you have an increased desire to take more lorazepam, tell your doctor.

Never provide this drug to someone else, especially if they have a history of drug abuse or addictions. Place the prescription in a safe place where others will not be able to get it. It is impossible to trade or give away this drug.

What is Diazepam?

Diazepam is an anti-anxiety and anti-agitation drug used to treat anxiety and agitation due to alcohol withdrawal. It's also used in combination with other medications to treat muscle pain and stiffness caused by conditions like Down syndrome, partial paralysis, and stiff-man disease. To treat convulsions, diazepam is usually used with other medications. Diazepam is a benzodiazepine, which means it belongs to a group of drugs called benzodiazepines. It works by calming abnormal brain activity.

For oral administration, diazepam is offered as a tablet, a solution, and a concentrate (liquid). It's usually taken once to four times a day, with or without food. Follow your medicine label's instructions to the letter, and ask your doctor or pharmacist to explain any parts you don't understand. Diazepam should be taken exactly as directed by the doctor.

Diazepam has a high potential for addiction. Do not violate your doctor's recommended dosage, frequency, or duration. If you have ever taken excessive amounts of alcohol, if you use or have ever used illicit substances, or if you have abused prescribed drugs, tell your doctor. Do not drink alcohol or use illegal narcotics during your therapy.

If you develop any of the following symptoms, call your doctor or go to the nearest emergency room straight away dizziness, extreme tiredness, delayed or troubled breathing, or a lack of responsiveness are all signs to look out for.

Take this medication orally, with or even without food, as prescribed by the doctor. Whether you're taking this medication in liquid form, use a special measuring device/spoon to accurately measure the dose. If you use a standard spoon, you could not get the proper medication.

Use the medicine dropper provided to combine the measured dose with a small amount of liquid or soft food if you've used the concentrated solution. Take all of the mixtures as quickly as possible. Never save the mixture to use later.

Your medical condition, age, and treatment response all influence the dosage. Do not increase your dosage or use this drug more frequently or for a longer period than recommended. You won't improve any faster, and you'll be more related to serious outcomes. When it's time to quit taking the medicine, do it properly.

It's possible that if you take this medication for an extended period, it won't work as well. Check with your doctor if this drug isn't performing as well as it once before.

Even though it aids a large number of people, this medication has the potential to cause addiction. Your chances are even better if you have a substance abuse problem. Take this medication exactly as directed to reduce the risk of addiction.

Main Differences Between Lorazepam and Diazepam in Points

  • Lorazepam and Diazepam differ a lot in that Lorazepam leave the body more quickly, reducing the risk of toxicity or side effects.
  • Lorazepam also has fewer adverse interactions with other pharmaceuticals than Diazepam, which can have bad side effects when combined with other medications.
  • Lorazepam is more effective than Diazepam at preventing ketamine-related comorbidities from developing.
  • Lorazepam is significantly more expensive than Diazepam.
  • characterized Diazepam can cause neutropenia, which is characterized by a hazardous decrease in the body's amount of white blood cells, and Lorazepam can cause extrapyramidal signs, which are distinguished by a range of drug-induced spontaneous muscle motions.
  • Both lorazepam and diazepam are excellent sedatives. Diazepam has a longer quarter in the body than lorazepam. This will not, however, imply that it is a superior medicine. The effectiveness of the benzodiazepine will be shaped by a range of factors, including the condition being treated. Consult a medical professional to determine the right plan of action for you.
  • Both benzodiazepines, lorazepam and diazepam, are benzodiazepines, although they are not the same. They are available in a multitude of formulations and have a range of FDA-approved applications. There are also various age restrictions: Lorazepam is not suggested for children under the age of 12, and diazepam is not indicated for babies under the age of six months.
  • Lorazepam and diazepam mainly interact with other central nervous system depressants (CNS). Taking these benzodiazepines alongside other medications that depress the central nervous system, such as analgesics, benzodiazepines, antipsychotics, antidepressants, and anticonvulsants, can cause dizziness, bewilderment, and drowsiness. Probenecid, an anti-gout medicine, can alter benzodiazepine metabolism, leading to increased side effects.


The benzodiazepines Lorazepam and Diazepam are Schedule 1 controlled drugs. Those with a history of alcohol or drug abuse are more likely to become dependent on and abuse benzodiazepines. Benzodiazepine fatality can be increased by addiction and usage. Benzodiazepine addiction can cause extreme loss of control, seriously impaired blood circulation, respiratory distress, and coma, among other things.

Use only the smallest amount of lorazepam or diazepam that is effective. Other possible precautions and restrictions should be explored with a doctor or healthcare provider. Lorazepam and Diazepam are both effective drugs. Blending alcohol and benzodiazepines is not a good idea. Both alcohol and benzodiazepines can cause the ability to cause CNS side effects like drowsiness and confusion.

Lorazepam was first marketed in 1977, and diazepam was first introduced in 1963. Lorazepam is mostly used to treat anxiety and epilepsy, causing drowsiness and primarily anterograde amnesia, whereas diazepam is primarily used to treat anxiety, insomnia, and panic attacks. Its application in seizures is ineffective since it takes a long time to take action. Because lorazepam has a larger molecular strength than diazepam, it is found in greater levels in the blood, even in little dosages. Diazepam withdrawal symptoms are less than lorazepam withdrawal symptoms.

Opioids should never be used with benzodiazepines. When benzodiazepines and opioids are consumed together, they can cause respiratory depression, coma, and even death. When these two kinds of medications are administered concurrently, patients should be properly watched.


  1. https://www.singlecare.com/blog/lorazepam-vs-diazepam/
  2. https://www.drugs.com/lorazepam.html
  3. https://www.webmd.com/drugs/2/drug-6306/diazepam-oral/details


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"Difference Between Lorazepam and Diazepam." Diffzy.com, 2024. Sat. 02 Mar. 2024. <https://www.diffzy.com/article/difference-between-lorazepam-and-diazepam-408>.

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