Difference Between Amphetamine and Dextroamphetamine

Edited by Diffzy | Updated on: April 30, 2023


Difference Between Amphetamine and Dextroamphetamine

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The dextrorotary stereoisomer of the actual amphetamine molecule is dextroamphetamine. It operates as a stimulant, enhancing alertness while decreasing weariness and, in certain cases, hunger. It is also the correct stereoisomer of amphetamine, with levoamphetamine on either side.

Amphetamine is a stimulator that works by boosting the heart rate and blood pressure of the person taking it, causing them to become more active.

The medicine is most frequently used to treat attention deficit hyperactivity disorder (ADHD) and accident-related brain injuries. Dextroamphetamine, on the other hand, is mostly used to treat ADHD. A Romanian scientist, Lazar Edeleanu, developed amphetamine medicines in Germany in 1887.

Edelman also discovered and produced dextroamphetamine under the chemical name "phenylisopropylamine" for use. The finding of normal drug use in the 1970s led to the conclusion that it might be a highly addictive medication that could be abused if used regularly.

Amphetamine vs. Dextroamphetamine

Amphetamine is known to raise cardiac output and blood pressure, which are both restrictions. As a result, this medicine is frequently banned for usage by persons who have heart problems or high blood pressure.

Some evidence suggests that taking the medications alongside MAOIs (monoamine oxidase inhibitors) can result in life-threatening conditions. Another side effect or contraindication of the medications is that they can cause excessive mydriasis or pupil dilation.

Advanced arteriosclerosis, symptomatic heart problems, hypersensitivity, and glaucoma are all contraindications of dextroamphetamine use. It's also worth noting that people who combine MAOI medications with dextroamphetamine may experience hypertension emergencies.

Powders, crystalline forms, and rocky outcrops are all examples of amphetamine. It may also be available in pill form or in the form of a substance that can be soaked in water. Dextroamphetamine, on the other side, is available in pill or tablet form. The application of the amphetamine varies depending on the purpose for which it will be used. This is because the medications are frequently viewed as performance enhancers that can boost a person's level of activity. Athletes utilize the substance to maintain a high degree of mental health and awareness. The US Air Force, on the other hand, accepts and recommends dextroamphetamine for use by its pilots as a means of increasing alertness and consciousness while on multiple missions.

Dextroamphetamine is a right-hand side stereoisomer of amphetamine, whereas amphetamine is a substance in and of itself. Amphetamine is prescribed for people with both a head injury and ADHD, whereas dextroamphetamine is only prescribed for ADHD patients.

Amphetamine exists in a variety of forms, including pills, powder, and crystalline compounds, whereas dextroamphetamine is mostly found in pill and tablet form. Amphetamine is primarily utilized by athletes as an illicit means to increase their performance, but dextroamphetamine is advised by the United States Air Force for its pilots.

The drugs Dexedrine and Adderall are used to treat ADHD. Moderate to severe mental fogginess, limited attention span, hyperactivity, and impulsiveness are all symptoms of ADHD. ADHD can hurt a negative impact on academic and professional performance, as well as fundamental everyday functioning if left untreated.

Both Dexedrine and Adderall are prescribed for the treatment of narcolepsy. Narcolepsy is a sleep disorder that causes excessive and uncontrollable daytime sleepiness. Untreated narcolepsy, like ADHD, can hurt a negative impact on daily activities.

Dexedrine is being used off-label in the treatment of obesity that has not responded to other interventions such as dieting, fitness, group programs, or other medicines for a short period (a few weeks).  Only your doctor can determine the best course of action for your condition.

Difference Between Amphetamine and Dextroamphetamine in Tabular Form

Parameter Amphetamine Dextroamphetamine
Classification of drug Stimulants for the central nervous system.


Stimulants for the central nervous system.
Status of the brand/generic There are both brand and generic options available.


There are both brand and generic options available.
What is the generic name of this drug? Sulfate of dextroamphetamine. Sulfate of dextroamphetamine.
In what form does the medication come? Extended-release capsules, tablets. Extended-release capsules, tablets.
What is the typical dose? 5 mg or twice daily, gradually increasing to 40 mg/day. 5 mg once or twice daily, gradually increasing to 40 mg/day.
What is the average length of treatment? Long-term planning.


Long-term planning.
Who is the average user of the medication? Adolescents and children Adults and children aged 3 and up.


Adolescents and children Adults and children aged 3 and up.
Side effects Amphetamine has a variety of negative effects, ranging from psychological to physical. Fainting, decreased appetite, migraines, and other physical symptoms are common. Diarrhea, mouth dryness, numbness, and mood disturbances are all known side effects of dextroamphetamine.
Work cycle Nerve stimulating hormones such as dopamine and norepinephrine are increased by amphetamine. Dextroamphetamine is a stimulant that increases the production of dopamine-like chemicals in the body.

What is Amphetamine?

Amphetamine is a drug used to treat persons with attention deficit hyperactivity disorder (ADHD). ADHD, or attention deficit hyperactivity disorder, is a prevalent disease that affects youngsters and causes them to experience anxiety about minor matters, stress, depression, overcomplicating, and other symptoms.

Amphetamine is a blend of two salts, primarily l-amphetamine and d-amphetamine, and it is a greater dose utilized for therapy due to the combination of the two. A percentage of additional binders is also included in the drug to ensure that the body functions properly. For optimum functioning, the ratio of the two main salts was established to be 3:1, with 3 representing d-amphetamine.

Amphetamine is available in two forms: pills and capsules. The drug is released over a longer period in capsule form. The drug is supposed to enhance dopamine and norepinephrine levels, which are nerve-activating hormones. As these levels rise, the person becomes calmer, which helps to relieve stress.

The drug has a wide range of physiological effects. The consequences, as well as their resistance to it, differ between individuals. Some people may have headaches, dizziness, and a loss of appetite, as well as mental health issues such as depression and mood swings, which can harm heart health.

Amphetamine is a potent central nervous system stimulant. It's used to treat a variety of ailments, but it's also extremely addictive and has a long history of abuse.

Attention deficit hyperactivity disorder is treated with stimulants like amphetamine and methylphenidate. Stimulants, and used as prescribed, can be both safe and efficacious.

Speed, or amphetamine sulfate, is also used recreationally and for non-medical purposes. It can cause exhilaration and inhibit the appetite, resulting in weight reduction. Stimulants, when used outside of the medical environment, can also have serious negative effects.

Types of Amphetamine

Ritalin and Concerta: Concerta, Ritalin (Methylphenidate) The amphetamine Methylphenidate is sold under the brand names Ritalin and Concerta. Doctors may legally prescribe it to patients with ADHD and narcolepsy. The US Food and Drug Administration has cleared methylphenidate for usage as prescribed under the supervision of medical professionals and for the intended purpose. Methylphenidate abuse is harmful and potentially life-threatening, according to the FDA.

Adderall: Adderall is a mixture of the stimulant amphetamine and dextroamphetamine with the brand name Adderall. The FDA has approved Adderall for use in the treatment of narcolepsy and ADHD in the United States. The FDA has issued several cautions about the potential for abuse of Adderall and other prescription stimulants if they are not used properly under the supervision of a trained physician. Warnings about the potential heart hazards of using stimulants to treat ADHD have been issued in several countries.

Ephedrine: Ephedrine is a tonic that is commonly used to treat breathing problems, asthma, allergies, and clogged sinuses. Ephedrine is a fundamental component of the illicit drug methamphetamine. It's also been found in a variety of diet drinks, each of which has a varied legal recognition in different nations.

What is Dextroamphetamine?

Dextroamphetamine is another medication used to treat attention deficit hyperactivity disorder, also known as ADHD. Being cut off from the surroundings, having mood swings, still being frustrated, and so on are all classic symptoms of the disorder. The drug is safe for anyone over the age of three, yet the sickness is fairly frequent among kids.

Dextroamphetamine is a weaker form of Adderall that primarily contains d-amphetamine. Even though they are used for the same treatment, the absence of one of the salts makes it less detrimental to the patients' health. It also affects the heart and lungs, albeit in a minor way.

The drugs are usually intended to be taken over a long period. The generic term for dextrin is dextroamphetamine, which is less expensive. It is available in two forms: span capsules, which release the contents of the capsules over a longer period, and extended capsules, which release the contents of the capsules for a longer amount of time.

In addition, the drug has a variety of physical and emotional impacts on the body. Headaches, loss of appetite, dry mouth, and other physical effects are common, whereas mood swings, anger, and annoyance over a shorter length of time are common mental consequences.

ADHD (attention deficit hyperactivity disorder) is addressed with just this drug. It works by changing the levels of certain natural compounds in the cortex. Dextroamphetamine belongs to the stimulant class of medicines. It can help you to improve your span of attention, stay focused on the task, and handle behavioral issues. It may also aid in the organization of your activities and the development of your listening abilities.

This medicine is also used to assist you to stay awake during the day if you have a certain sleeping condition. It should not be used to treat fatigue or prevent sleep in those who do not have sleep problems.

Differences Between Amphetamine and Dextroamphetamine in Points

  • Amphetamine is made up of two types of salt, d-amphetamine, and l-amphetamine, in a 3:1 ratio, whereas Dextroamphetamine is the general term for a salt that is mostly d-amphetamine.
  • Adderall is the brand name for amphetamine. In comparison, Dextroamphetamine is known by the brand name Dexedrine.
  • Dextroamphetamine is also available in capsules and the spansule form, whereas Amphetamine is accessible in two forms: tablets and extended-release capsules.
  • Dextroamphetamine is responsible for raising the production of hormones like dopamine inside the body, whereas amphetamine enhances the levels of nerve stimulating hormones like dopamine and norepinephrine.
  • Amphetamine has a variety of negative effects, ranging from cognitive to physiological. Fainting, decreased appetite, headache, and other physical symptoms are common. Dextroamphetamine, on the other hand, is known to cause a variety of adverse effects, including diarrhea, mouth-drying, and numbness or change.
  • Dexedrine is a brand name for dextroamphetamine sulfate, which is a generic drug. It's a CNS stimulant, and it's a form of amphetamine in particular.
  • Amphetamines stimulate the release of norepinephrine, and the cerebral cortex is the principal location of this activity. Amphetamines stimulate the central nervous system, resulting in decreased weariness, greater motor activity and alertness, and an improved mood.
  • The FDA has approved Dexedrine (Dexedrine information) for the treatment of ADHD and narcolepsy. It's also used off-label, or without FDA clearance, in the treatment of obesity that hasn't responded to previous treatments.
  • Dexedrine comes in a variety of forms, including immediate-release tablets, capsules, and extended-release capsules.


The two most prevalent drugs used to treat ADHD are amphetamine and dextroamphetamine. Because of the way we live and have, the disease is getting more widespread these days. The way we live is changing, and we're deciding to spend more time indoors. Dextroamphetamine is made up of only one salt, whereas amphetamine is made up of two salts, l-amphetamine, and d-amphetamine. Amphetamine is more potent and has a greater impact on the heart and lungs. Amphetamine is used to treat more severe forms of ADHD, and both medications have side effects such as dizziness, mood changes, and itching.

Both medications have approximately similar efficacy and safety characteristics. However, because everyone reacts to medication differently, you may find that one prescription works better for you than the other. Your doctor may prescribe one medicine and then the other to see which one works best for you.

You might also get side effects from one drug that you don't experience from the other. Within a few days of starting a new medicine, you should know whether it is beneficial and how well you tolerate the adverse effects. Although dextroamphetamine and amphetamine are more commonly prescribed, that doesn't imply you wouldn't do as well or better on dextroamphetamine.


  • https://www.singlecare.com/blog/dexedrine-vs-adderall/
  • https://adf.org.au/drug-facts/amphetamines/


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"Difference Between Amphetamine and Dextroamphetamine." Diffzy.com, 2024. Sat. 18 May. 2024. <https://www.diffzy.com/article/difference-between-amphetamine-and-dextroamphetamine-255>.

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